The Challenge

A mid-sized biotech company was preparing to launch a first-in-class therapy for a rare autoimmune condition.
The clinical data were strong, but when the global market access team reviewed the draft Global Value Dossier (GVD), they found:

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• The document was a collection of data points without a clear value narrative.
   

• There was no explicit connection between clinical results, economic models, and patient impact.
   

• Local affiliates would need significant rework to prepare HTA submissions and payer materials, risking delayed launch readiness and inconsistent messaging across regions.
   

 

Our Approach

We restructured the GVD to transform it from a static evidence repository into a strategic value communication playbook:

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🔹 Framed the Unmet Need
Clearly quantified epidemiology, patient burden, and health system costs to justify urgency.

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🔹 Integrated Evidence into a Narrative
Connected efficacy, safety, and HRQoL results to downstream economic and clinical outcomes, showing how the therapy changed the disease trajectory.

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🔹 Mapped Payer-Relevant Value Drivers
Aligned budget impact, treatment pathway changes, and cost-offsets with top payer concerns in major markets.

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🔹 Added Transparency and Action Plan
Included a section on evidence gaps and future real-world evidence (RWE) plans to proactively address HTA expectations.

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🔹 Enabled Localization
Created modular content and templates to allow affiliates to adapt the story for local HTA dossiers, AMCP submissions, and payer slide decks efficiently.

 

The Results

✔️ Faster Local Adaptation – Affiliates reduced local dossier development time by 40%.

✔️ Aligned Messaging – Consistent payer value messaging across EU5, Canada, and APAC.

✔️ Stronger HTA Readiness – Early feedback from affiliate teams indicated higher confidence in local submissions and payer negotiations.

✔️ Global Playbook Adoption – The GVD became the single source of truth for market access, medical affairs, and HEOR teams.

 

The Insight
A GVD should be more than a warehouse of data — it should be a strategic tool that tells a persuasive story and equips affiliates to execute efficiently.

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👉 Lesson Learned: The strongest launches start with a value story that is globally consistent yet locally adaptable, enabling every affiliate to speak with one voice to payers and HTAs.